Agentic Connectomic Proofreading

Automated proofreading of a full brain connectome using Neuroglancer with a computer-using agent.


Developing an end-to-end pipeline for a computer-using agent/foundation model capable of autonomously proofreading a full brain connectome in Neuroglancer. See here for more (not updated) information on connectomics/proofreading. See here for a Python repository (written with Raphaël Levisse) that simplifies interactions with Neuroglancer.

EM collection and image analysis has enabled the release of a full wiring diagram of a fly brain. Scaling towards full mouse (and potentially human) connectomes will require significant innovation in both image segmentation and proofreading to deal with the petabyte-scale amounts of data involved.

Proofreading - manual verification of neurons and their wirings - is an expensive and time-consuming bottleneck preventing such scaling.